Microvascular Management of Systemic Insulin Sensitivity
نویسندگان
چکیده
منابع مشابه
Microvascular management of systemic insulin sensitivity.
M icrovascular disease is a well-recognized complication of long-standing diabetes mellitus and is preceded by impaired vasoreactivity, a consequence largely of decreased endothelial cell (EC) generation of NO. This loss of normal vasodilation is evident particularly in EC responses to insulin and may arise early in states of obesity and insulin resistance. In addition, ECs serve as purveyors o...
متن کاملSystemic nitric oxide synthase inhibition increases insulin sensitivity in man.
1. Recent evidence shows that skeletal muscle blood flow is an important determinant of insulin sensitivity and that insulin-mediated vasodilatation is nitric oxide dependent. These results have given rise to the hypothesis that endothelial nitric oxide inhibition may decrease insulin sensitivity in humans. 2. We examined this hypothesis directly by evaluating the effects of systemic nitric oxi...
متن کاملMicrovascular Contributions to Insulin Resistance
The notion that type 2 diabetes and insulin resistance are associated with many macroand microvascular defects (1,2) is unquestionable, but whether vascular defects precede and contribute to insulin resistance is less certain and has been a controversial topic. The most compelling evidence for a vascular involvement in insulin resistance has been in skeletal muscle (3), but recent research has ...
متن کاملMicrovascular function relates to insulin sensitivity and blood pressure in normal subjects.
BACKGROUND A strong but presently unexplained inverse association between blood pressure and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a common antecedent linking insulin sensitivity to blood pressure. To test this hypothesis, we studied 18 normotensive and glucose-tolerant subjects showing a wide range in insulin sensitivity as assessed with the hyperinsu...
متن کاملEndogenous insulin and insulin sensitivity
Results There was a significant inverse correlation between forearm blood flow and insulin sensitivity (r="0·67, P=0·03), patients with lesser degrees of insulin sensitivity having the greater forearm blood flows. There was no correlation with the other haemodynamic or neurohumoral parameters. Patients with greater insulin resistance tended to have higher circulating endogenous insulin levels, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.278382